| 88 | Jacobson DL, Crider KS, DeMarrais P, Brummel S, Zhang M, Pfeiffer CM, Moore CA, McCarthy K, Johnston B, Mohammed T, Vhembo T, Kabugho E, Muzorah GA, Cassim H, Fairlie L, Machado ES, Ngocho JS, Shapiro RL, Serghides L, … Lockman S. Dolutegravir- versus efavirenz-based treatment in pregnancy: Impact on red blood cell folate concentrations in pregnant women and their infants. J Infect Dis. 2024 Jun 15; jiae308. | FULL TEXT PMID: 38877762 | ||
| 87 | Dhume S, Balogun K, Sarkar S, Acosta S, Mount HTJ, Cahill LS, Sled JG, Serghides L. Perinatal exposure to atazanavir-based antiretroviral regimens in a mouse model leads to differential long-term motor and cognitive deficits dependent on the NRTI backbone. Front Mol Neurosci. 2024 Apr 5; 17:1376681. | FULL TEXT PMID: 38646101 | ||
| 86 | Varo R, Crowley VM, Mucasse H, Sitoe A, Bramugy J, Serghides L, Weckman AM, Erice C, Bila R, Vitorino P, Mucasse C, Valente M, Ajanovic S, Balanza N, Zhong K, Derpsch Y, Gladstone M, Mayor A, Bassat Q, Kain KC. Adjunctive rosiglitazone treatment for severe pediatric malaria: A randomized placebo-controlled trial in Mozambican children. Int J Infect Dis. 2023 Nov 25; 139:34-40. | FULL TEXT PMID: 38013152 | ||
| 85 | Fisher SA, Jao KJ, Yee LM, Serghides L, Chadwick EG, Jacobson DL. Association of Fatty Acid Signatures with HIV Viremia in Pregnancy. AIDS Res Hum Retroviruses. 2023 Oct 30; 10.1089/AID.2023.0040. | FULL TEXT PMID: 37772708 | ||
| 84 | Mohan H, Nguyen J, MacKenzie B, Yee A, Laurette EY, Sanghvi T, Tejada O, Dontsova V, Leung KY, Goddard C, De Young T, Sled JG, Greene NDE, Copp AJ, & Serghides L. Folate deficiency increases the incidence of dolutegravir-associated foetal defects in a mouse pregnancy model. EBioMedicine. 2023 Aug 14; 95(104762), 104762. | FULL TEXT PMID: 37586112 | ||
| 83 | Dontsova V, Mohan H, Blanco C, Jao J, Greene NDE, Copp AJ, Zash R, & Serghides L. Metabolic implications and safety of dolutegravir use in pregnancy. Lancet HIV. 2023 Aug 4; 10(9):e606-e616. | FULL TEXT PMID: 37549681 | ||
| 82 | Shiau S, Jacobson DL, Huo Y, Kacanek D, Yee LM, Williams DB, Haddad LB, Serghides L, Powis K, Sperling RS, Williams PL, Jao J & Pediatric HIV/AIDS Cohort Study. Unique Profile of Inflammation and Immune Activation in Pregnant People With HIV in the United States. J Infect Dis. 2023 Mar 1; 227(5):720-730. | FULL TEXT PMID: 36592383 | ||
| 81 | Aker A, Serghides L, Cotnam J, Jackson R, Robinson M, Gauvin H, Mushquash C, Gesink D, Amirault M, & Benoit AC. The impact of a stress management intervention including cultural components on stress biomarker levels and mental health indicators among indigenous women. J Infect Dis. 2023 Jan 18. | FULL TEXT PMID: 36652086 | ||
| 80 | Smith MR, Mohan H, Ajaykumar A, Hsieh AYY, Martineau L, Patel R, Gadawska I, Sherwood C, Serghides L, Piret JM, & Côté HCF. Second-Generation Human Immunodeficiency Virus Integrase Inhibitors Induce Differentiation Dysregulation and Exert Toxic Effects in Human Embryonic Stem Cell and Mouse Models. J Infect Dis. 2022 Nov 28; 226(11):1992-2001. | FULL TEXT PMID: 36124861 | ||
| 79 | Medeiros P, Warren L, Kazemi M, Massaquoi N, Smith S, Tharao W, Serghides L, Logie CH, Kroch A, Burchell AN, de Pokomandy A, Kaida A, Loutfy M, & CHIWOS Research Team. HIV care cascade for women living with HIV in the Greater Toronto Area versus the rest of Ontario and Canada. Int J STD AIDS. 2022 Nov 21; 34(1):4-17. | FULL TEXT PMID: 36411243 | ||
| 78 | Saghian R, Cahill LS, Debebe SK, Rahman A, Serghides L, McDonald CR, Weckman AM, Kain KC, & Sled JG. Allometric scaling relationships in mouse placenta. J R Soc Interface. 2022 Nov 9; 19(196):20220579. | PDF PMID: 36349448 | ||
| 77 | Mohan H, Atkinson K, Watson B, Brumme, CJ, & Serghides L. A Pharmacokinetic Dose-Optimization Study of Cabotegravir and Bictegravir in a Mouse Pregnancy Model. Pharmaceutics. 2022 Aug 24; 14(9):1761. | FULL TEXT PMID: 36145509 | ||
| 76 | Balogun K, & Serghides L. Comparison of the Effects of Three Dual-Nucleos(t)ide Reverse Transcriptase Inhibitor Backbones on Placenta Mitochondria Toxicity and Oxidative Stress Using a Mouse Pregnancy Model. Pharmaceutics. 2022 May 15; 14(5):1063. | FULL TEXT PMID: 35631648 | ||
| 75 | Gilmore JC, Hoque MT, Dai W, Mohan H, Dunk C, Serghides L, & Bendayan R. Interaction between dolutegravir and folate transporters and receptor in human and rodent placenta. EBioMedicine. 2021 Dec 23; 75:103771. | FULL TEXT PMID: 34954655 | ||
| 74 | Kala S, Meteleva K, & Serghides L. ACE2, TMPRSS2, and L-SIGN Expression in Placentae From HIV-Positive Pregnancies Exposed to Antiretroviral Therapy-Implications for SARS-CoV-2 Placental Infection. J Infect Dis. 2021 Dec 8; 224(Supplement_6):S631-S641. | FULL TEXT PMID: 33880537 | ||
| 73 | Dunk CE, & Serghides L. Protease inhibitor-based antiretroviral therapy in pregnancy: effects on hormones, placenta, and decidua. Lancet HIV. 2021 Dec 2; 9(2):e120-e129. | FULL TEXT PMID: 34863352 | ||
| 72 | Shinar S, Agrawal S, Ryu M, Walmsley S, Serghides L, Yudin MH, & Murphy KE. Perinatal outcomes in women living with HIV-1 and receiving antiretroviral therapy – a systematic review and meta-analysis. Acta Obstet Gynecol Scand. 2021 Oct 27; 101(2):168-182. | FULL TEXT PMID: 34704251 | ||
| 71 | Roberts DJ, Edlow AG, Romero RJ, Coyne CB, Ting DT, Hornick JL, Zaki SR, Adhikari UD, Serghides L, Gaw SL, Metz TD; all members of the NIH/NICHD SARS-CoV-2 Placental Infection Workshop. SPECIAL REPORT: A standardized definition of placental infection by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a consensus statement from the National Institutes of Health/Eunice Kennedy Shriver National Institute of Child Health and Human Development (NIH/NICHD) SARS-CoV-2 placental infection workshop. Am J Obstet Gynecol. 2021 Aug 5:S0002-9378(21)00832-2. | FULL TEXT PMID: 34364845 | ||
70 | Cahill LS, Mercer GV, Jagota D, Ravi Chandran A, Milligan N, Shinar S, Whitehead CL, Hobson SR, Serghides L, Parks WT, Macgowan CK, Kingdom JC, Sled JG, Baschat AA. Doppler Ultrasound of the Fetal Descending Aorta: An Objective Tool to Assess Placental Blood Flow Resistance in Pregnancies with Discordant Umbilical Arteries. J Ultrasound Med. 2021 Jul 6. | PDF PMID: 34228375 | ||
| 69 | Gilmore JC, Zhang G, Cameron DW, Serghides L, Bendayan R. Impact of in utero antiretroviral drug exposure on expression of membrane-associated transporters in mouse placenta and fetal brain. AIDS 2021 Jun 25. | PDF PMID: 34175869 | ||
| 68 | Cahill LS, Stortz G, Ravi Chandran A, Milligan N, Shinar S, Whitehead CL, Hobson SR, Ayyathurai V, Rahman A, Saghian R, Jobst KJ, McShane C, Block-Abraham D, Seravalli V, Laurie M, Millard S, Delp C, Wolfson D, Baschat AA, Murphy KE, Serghides L, Morgen E, Macgowan CK, Parks WT, Kingdom JC, Sled JG. Wave reflections in the umbilical artery measured by Doppler ultrasound as a novel predictor of placental pathology. EBioMedicine 67 (2021) 103326. | FULL TEXT PMID: 33965347 | ||
| 67 | Kala S, Meteleva K, Serghides L. ACE2, TMPRSS2 and L-SIGN expression in placentae from HIV-positive pregnancies exposed to antiretroviral therapy-implications for SARS-CoV-2 placental infection. J Infect Dis. 2021 Apr 21:jiab166. | FULL TEXT PMID: 33880537 | ||
| 66 | Mohan H, Guzman Lenis M, Laurette EY, Tejada O, Sanghvi T, Leung KY, Cahill LS, Sled JG, Delgado-Olguín P, Greene NDE, Copp AJ, Serghides L. In response to the Letter to the Editor by Romach et al. re our publication “Dolutegravir in pregnant mice is associated with increased rates of fetal defects at therapeutic but not at supratherapeutic levels”. EBioMedicine. 2021 Apr;66:103334. | FULL TEXT PMID: 33862586 | ||
| 65 | Jagota D, George H, Walker M, Ravi Chandran A, Milligan N, Shinar S, Whitehead CL, Hobson SR, Serghides L, Parks WT, Baschat AA, Macgowan CK, Sled JG, Kingdom JC, Cahill LS. Sex differences in fetal Doppler parameters during gestation. Biol Sex Differ. 2021 Mar 10;12(1):26. | FULL TEXT PMID: 33691774 | ||
| 64 | Paranavitana L, Walker M, Chandran AR, Milligan N, Shinar S, Whitehead CL, Hobson SR, Serghides L, Parks WT, Baschat AA, Macgowan CK, Sled JG, Kingdom JC, Cahill LS. Sex differences in uterine artery Doppler during gestation in pregnancies complicated by placental dysfunction. Biol Sex Differ. 2021 Feb 2;12(1):19. | FULL TEXT PMID: 33531040 | ||
| 63 | Cahill LS, Shinar S, Whitehead CL, Hobson SR, Stortz G, Ayyathurai V, Ravi Chandran A, Rahman A, Kingdom JC, Baschat A, Murphy KE, Serghides L, Macgowan CK, Sled JG. Sex differences in modulation of fetoplacental vascular resistance in growth-restricted mouse fetuses following betamethasone administration: comparisons with human fetuses. Am J Obstet Gynecol MFM. 2021 Jan;3(1):100251. | FULL TEXT PMID: 33451599 | ||
| 62 | Mohan H, Lenis MG, Laurette EY, Tejada O, Sanghvi T, Leung KY, Cahill LS, Sled JG, Delgado-Olguín P, Greene NDE, Copp AJ, Serghides L. Dolutegravir in pregnant mice is associated with increased rates of fetal defects at therapeutic but not at supratherapeutic levels. EBioMedicine. 2021 Jan;63:103167. | FULL TEXT PMID: 33341441 | ||
| 61 | Yampolsky M, Shlakhter O, Deng D, Kala S, Walmsley SL, Murphy KE, Yudin MH, MacGillivray J, Loutfy M, Dunk C, Serghides L. Exploring the impact of HIV infection and antiretroviral therapy on placenta morphology. Placenta. 2021 Jan 15;104:102-109. | FULL TEXT PMID: 33310298 | ||
| 60 | Sarkar A, Balogun K, Guzman Lenis MS, Acosta S, Mount HT, Serghides L. In utero exposure to protease inhibitor-based antiretroviral regimens delays growth and developmental milestones in mice. PLoS One. 2020 Nov 19;15(11):e0242513. | FULL TEXT PMID: 33211746 | ||
| 59 | Kojovic D, Ghoneim RH, Serghides L, Piquette-Miller M. Role of HIV and Antiretroviral Therapy on the Expression of Placental Transporters in Women with HIV. AAPS J. 2020 Oct 25;22(6):138. | PMID: 33099683 | ||
| 58 | Gilmore JC, Serghides L, Bendayan R. Differential effects of antiretroviral drug toxicity in male versus female children who are HIV-exposed but uninfected. AIDS. 2021 Jan 1;35(1):1-14. | PMID: 33048885 | ||
| 57 | Kala S, Dunk C, Acosta S, Serghides L. Periconceptional exposure to lopinavir, but not darunavir, impairs decidualization: a potential mechanism leading to poor birth outcomes in HIV-positive pregnancies. Hum Reprod. 2020 Aug 1;35(8):1781-1796. | FULL TEXT PMID: 32712670 | ||
| 56 | Debebe SK, Cahill LS, Kingdom JC, Whitehead CL, Chandran AR, Parks WT, Serghides L, Baschat A, Macgowan CK, Sled JG. Wharton’s jelly area and its association with placental morphometry and pathology. Placenta. 2020 May;94:34-38. | FULL TEXT PMID: 32421532 | ||
| 55 | Cahill LS, Whitehead CL, Hobson SR, Stortz G, Kingdom JC, Baschat A, Murphy KE, Serghides L, Macgowan CK, Sled JG. Effect of maternal betamethasone administration on feto-placental vascular resistance in the mouse†. Biol Reprod. 2019 Oct 25;101(4):823-831. | FULL TEXT PMID: 31318405 | ||
| 54 | McHenry MS, Balogun KA, McDonald BC, Vreeman RC, Whipple EC, Serghides L. In utero exposure to HIV and/or antiretroviral therapy: a systematic review of preclinical and clinical evidence of cognitive outcomes. J Int AIDS Soc. 2019 Apr;22(4):e25275. | FULL TEXT PMID: 30983111 | ||
| 53 | Sled JG, Stortz G, Cahill LS, Milligan N, Ayyathurai V, Serghides L, Morgen E, Seravalli V, Delp C, McShane C, Baschat A, Kingdom J, Macgowan CK. Reflected hemodynamic waves influence the pattern of Doppler ultrasound waveforms along the umbilical arteries. Am J Physiol Heart Circ Physiol. 2019 May 1;316(5):H1105-H1112. | FULL TEXT PMID: 30794433 | ||
| 52 | Cahill LS, Zhou YQ, Hoggarth J, Yu LX, Rahman A, Stortz G, Whitehead CL, Baschat A, Kingdom JC, Macgowan CK, Serghides L, Sled JG. Placental vascular abnormalities in the mouse alter umbilical artery wave reflections. Am J Physiol Heart Circ Physiol. 2019 Mar 1;316(3):H664-H672. | FULL TEXT PMID: 30632765 | ||
| 51 | Kala S, Watson B, Zhang JG, Papp E, Guzman Lenis M, Dennehy M, Cameron DW, Harrigan PR, Serghides L. Improving the clinical relevance of a mouse pregnancy model of antiretroviral toxicity; a pharmacokinetic dosing-optimization study of current HIV antiretroviral regimens. Antiviral Res. 2018 Nov;159:45-54. | PMID: 30236532 | ||
| 50 | Slogrove AL, Becquet R, Chadwick EG, Côté HCF, Essajee S, Hazra R, Leroy V, Mahy M, Murenga M, Wambui Mwangi J, Oyiengo L, Rollins N, Penazzato M, Seage GR 3rd, Serghides L, Vicari M, Powis KM. Surviving and Thriving-Shifting the Public Health Response to HIV-Exposed Uninfected Children: Report of the 3rd HIV- Exposed Uninfected Child Workshop. Front Pediatr. 2018 May 30;6:157. | FULL TEXT PMID: 29900165 | ||
| 49 | Mohammadi H, Papp E, Cahill L, Rennie M, Banko N, Pinnaduwage L, Lee J, Kibschull M, Dunk C, Sled JG, Serghides L. HIV antiretroviral exposure in pregnancy induces detrimental placenta vascular changes that are rescued by progesterone supplementation. Sci Rep. 2018 Apr 26;8(1):6552. | FULL TEXT PMID: 29700323 | ||
| 48 | Varo R, Crowley VM, Sitoe A, Madrid L, Serghides L, Kain KC, Bassat Q. Adjunctive therapy for severe malaria: a review and critical appraisal. Malar J. 2018 Jan 24;17(1):47. | FULL TEXT PMID: 29361945 | ||
| 47 | Wong JMH, Kanga N, Dogra N, Ngoma MS, Serghides L, Silverman M. Perceived acceptability of progesterone to prevent preterm births and low birth weight among HIV-infected and HIV-uninfected Zambian pregnant women. Int J Womens Health. 2017 Nov 16;9:827-833. | FULL TEXT PMID: 29180906 | ||
| 46 | McDonald CR, Conroy AL, Gamble JL, Papp E, Hawkes M, Olwoch P, Natureeba P, Kamya M, Silverman M, Cohan D, Koss CA, Dorsey G, Kain KC, Serghides L. Estradiol Levels Are Altered in Human Immunodeficiency Virus-Infected Pregnant Women Randomized to Efavirenz-Versus Lopinavir/Ritonavir-Based Antiretroviral Therapy. Clin Infect Dis. 2018 Jan 18;66(3):428-436. | FULL TEXT PMID: 29136115 | ||
| 45 | Balogun KA, Guzman Lenis MS, Papp E, Loutfy M, Yudin MH, MacGillivray J, Walmsley SL, Silverman M, Serghides L. Elevated Levels of Estradiol in Human Immunodeficiency Virus-Infected Pregnant Women on Protease Inhibitor-Based Regimens. Clin Infect Dis. 2018 Jan 18;66(3):420-427. | FULL TEXT PMID: 29020282 | ||
| 44 | Varo R, Crowley VM, Sitoe A, Madrid L, Serghides L, Bila R, Mucavele H, Mayor A, Bassat Q, Kain KC. Safety and tolerability of adjunctive rosiglitazone treatment for children with uncomplicated malaria. Malar J. 2017 May 23;16(1):215. | FULL TEXT PMID: 28535809 | ||
| 43 | Kennedy VL, Collins M, Yudin MH, Serghides L, Walmsley S, Angel JB, Ongoiba F, Powis J, Smaill F, Tharao W, Rachlis A, Silverman M, Sandre R, Regier DA, Loutfy M. Exploring the Factors Considered by People Living with HIV and Their Partners during Preconception. J Int Assoc Provid AIDS Care. 2017 May/Jun;16(3):239-246. | FULL TEXT PMID: 28485707 | ||
| 42 | Siou K, Walmsley SL, Murphy KE, Raboud J, Loutfy M, Yudin MH, Silverman M, Ladhani NN, Papp E, Serghides L. Erratum to: Progesterone supplementation for HIV-positive pregnant women on protease inhibitor-based antiretroviral regimens (the ProSPAR study): a study protocol for a pilot randomized controlled trial. Pilot Feasibility Stud. 2017 Apr 28;3:21. (Erratum for: Pilot Feasibility Stud. 2016 Aug 12;2:49.) | FULL TEXT PMID: 28461906 | ||
| 41 | Siou K, Walmsley SL, Murphy KE, Raboud J, Loutfy M, Yudin MH, Silverman M, Ladhani NN, Serghides L. Progesterone supplementation for HIV-positive pregnant women on protease inhibitor-based antiretroviral regimens (the ProSPAR study): a study protocol for a pilot randomized controlled trial. Pilot Feasibility Stud. 2016 Aug 12;2:49. (Erratum in: Pilot Feasibility Stud. 2017 Apr 28;3:21.) | FULL TEXT PMID: 27965866 | ||
| 40 | Ayi K, Lu Z, Serghides L, Ho JM, Finney C, Wang JCY, Liles WC, Kain KC. CD47-SIRPα Interactions Regulate Macrophage Uptake of Plasmodium falciparum-Infected Erythrocytes and Clearance of Malaria In Vivo. Infect Immun. 2016 Jun 23;84(7):2002-2011. | FULL TEXT PMID: 27091932 | ||
| 39 | Papp E, Balogun K, Banko N, Mohammadi H, Loutfy M, Yudin MH, Shah R, MacGillivray J, Murphy KE, Walmsley SL, Silverman M, Serghides L. Low Prolactin and High 20-α-Hydroxysteroid Dehydrogenase Levels Contribute to Lower Progesterone Levels in HIV-Infected Pregnant Women Exposed to Protease Inhibitor-Based Combination Antiretroviral Therapy. J Infect Dis. 2016 May 15;213(10):1532-40. | FULL TEXT PMID: 26740274 | ||
| 38 | Finney C, Serghides L. An In Vitro Model for Measuring Immune Responses to Malaria in the Context of HIV Co-infection. J Vis Exp. 2015 Oct 6;(104):52969. | FULL TEXT PMID: 26485041 | ||
| 37 | Serghides L, Finney CA, Ayi K, Loutfy M, Kain KC. Chronic HIV infection impairs nonopsonic phagocytosis of malaria parasites. J Acquir Immune Defic Syndr. 2015 Feb 1;68(2):128-32. | FULL TEXT PMID: 25415293 | ||
| 36 | Papp E, Mohammadi H, Loutfy MR, Yudin MH, Murphy KE, Walmsley SL, Shah R, MacGillivray J, Silverman M, Serghides L. HIV protease inhibitor use during pregnancy is associated with decreased progesterone levels, suggesting a potential mechanism contributing to fetal growth restriction. J Infect Dis. 2015 Jan 1;211(1):10-8. | FULL TEXT PMID: 25030058 | ||
| 35 | Serghides L, McDonald CR, Lu Z, Friedel M, Cui C, Ho KT, Mount HT, Sled JG, Kain KC. PPARγ agonists improve survival and neurocognitive outcomes in experimental cerebral malaria and induce neuroprotective pathways in human malaria. PLoS Pathog. 2014 Mar 6;10(3):e1003980. | FULL TEXT PMID: 24603727 | ||
| 34 | Chege D, Higgins SJ, McDonald CR, Shahabi K, Huibner S, Kain T, Kain D, Kim CJ, Leung N, Amin M, Geddes K, Serghides L, Philpott DJ, Kimani J, Gray-Owen S, Kain KC, Kaul R. Murine Plasmodium chabaudi malaria increases mucosal immune activation and the expression of putative HIV susceptibility markers in the gut and genital mucosae. J Acquir Immune Defic Syndr. 2014 Apr 15;65(5):517-25. | FULL TEXT PMID: 24256632 | ||
| 33 | Kennedy VL, Serghides L, Raboud JM, Su D, Blitz S, Hart TA, Walmsley SL, Angel JB, Smaill FM, Ralph ED, Tharao WE, Loutfy MR; Ontario HIV Fertility Research Team. The importance of motherhood in HIV-positive women of reproductive age in Ontario, Canada. AIDS Care. 2014;26(6):777-84. | PMID: 24206065 | ||
| 32 | Kim H, Erdman LK, Lu Z, Serghides L, Zhong K, Dhabangi A, Musoke C, Gerard C, Cserti-Gazdewich C, Liles WC, Kain KC. Functional roles for C5a and C5aR but not C5L2 in the pathogenesis of human and experimental cerebral malaria. Infect Immun. 2014 Jan;82(1):371-9. | FULL TEXT PMID: 24191300 | ||
| 31 | Finney CA, Ayi K, Wasmuth JD, Sheth PM, Kaul R, Loutfy M, Kain KC, Serghides L. HIV infection deregulates Tim-3 expression on innate cells: combination antiretroviral therapy results in partial restoration. J Acquir Immune Defic Syndr. 2013 Jun 1;63(2):161-7. | FULL TEXT PMID: 23314411 | ||
| 30 | Finney CA, Ayi K, Wasmuth JD, Sheth PM, Kaul R, Loutfy MR, Kain KC, Serghides L. HIV infection deregulates innate immunity to malaria despite combination antiretroviral therapy. AIDS. 2013 Jan 28;27(3):325-35. | FULL TEXT PMID: 23291537 | ||
| 29 | Miller C, Miller M, McMullin B, Regev G, Serghides L, Kain K, Road J, Av-Gay Y. A phase I clinical study of inhaled nitric oxide in healthy adults. J Cyst Fibros. 2012 Jul;11(4):324-31. | FULL TEXT PMID: 22520076 | ||
| 28 | Serghides L, Kim H, Lu Z, Kain DC, Miller C, Francis RC, Liles WC, Zapol WM, Kain KC. Inhaled nitric oxide reduces endothelial activation and parasite accumulation in the brain, and enhances survival in experimental cerebral malaria. PLoS One. 2011;6(11):e27714. | FULL TEXT PMID: 22110737 | ||
| 27 | Serghides L. The Case for the Use of PPARγ Agonists as an Adjunctive Therapy for Cerebral Malaria. PPAR Res. 2012;2012:513865. | FULL TEXT PMID: 21772838 | ||
| 26 | Hawkes M, Opoka RO, Namasopo S, Miller C, Conroy AL, Serghides L, Kim H, Thampi N, Liles WC, John CC, Kain KC. Nitric oxide for the adjunctive treatment of severe malaria: hypothesis and rationale. Med Hypotheses. 2011 Sep;77(3):437-44. | FULL TEXT PMID: 21745716 | ||
| 25 | Labbé K, Miu J, Yeretssian G, Serghides L, Tam M, Finney CA, Erdman LK, Goulet ML, Kain KC, Stevenson MM, Saleh M. Caspase-12 dampens the immune response to malaria independently of the inflammasome by targeting NF-kappaB signaling. J Immunol. 2010 Nov 1;185(9):5495-502. | FULL TEXT PMID: 20876354 | ||
| 24 | Stevenson MM, Gros P, Olivier M, Fortin A, Serghides L. Cerebral malaria: human versus mouse studies. Trends Parasitol. 2010 Jun;26(6):274-5. | PMID: 20382077 | ||
| 23 | Boggild AK, Krudsood S, Patel SN, Serghides L, Tangpukdee N, Katz K, Wilairatana P, Liles WC, Looareesuwan S, Kain KC. Use of peroxisome proliferator-activated receptor gamma agonists as adjunctive treatment for Plasmodium falciparum malaria: a randomized, double-blind, placebo-controlled trial. Clin Infect Dis. 2009 Sep 15;49(6):841-9. | FULL TEXT PMID: 19673614 | ||
| 22 | Serghides L, Patel SN, Ayi K, Lu Z, Gowda DC, Liles WC, Kain KC. Rosiglitazone modulates the innate immune response to Plasmodium falciparum infection and improves outcome in experimental cerebral malaria. J Infect Dis. 2009 May 15;199(10):1536-45. | FULL TEXT PMID: 19392627 | ||
| 21 | Conroy A, Serghides L, Finney C, Owino SO, Kumar S, Gowda DC, Liles WC, Moore JM, Kain KC. C5a enhances dysregulated inflammatory and angiogenic responses to malaria in vitro: potential implications for placental malaria. PLoS One. 2009;4(3):e4953. | FULL TEXT PMID: 19308263 | ||
| 20 | Patel SN, Berghout J, Lovegrove FE, Ayi K, Conroy A, Serghides L, Min-oo G, Gowda DC, Sarma JV, Rittirsch D, Ward PA, Liles WC, Gros P, Kain KC. C5 deficiency and C5a or C5aR blockade protects against cerebral malaria. J Exp Med. 2008 May 12;205(5):1133-43. | FULL TEXT PMID: 18426986 | ||
| 19 | Ayi K, Min-Oo G, Serghides L, Crockett M, Kirby-Allen M, Quirt I, Gros P, Kain KC. Pyruvate kinase deficiency and malaria. N Engl J Med. 2008 Apr 24;358(17):1805-10. | FULL TEXT PMID: 18420493 | ||
| 18 | Keen J, Serghides L, Ayi K, Patel SN, Ayisi J, van Eijk A, Steketee R, Udhayakumar V, Kain KC. HIV impairs opsonic phagocytic clearance of pregnancy-associated malaria parasites. PLoS Med. 2007 May;4(5):e181. | FULL TEXT PMID: 17535103 | ||
| 17 | Patel SN, Lu Z, Ayi K, Serghides L, Gowda DC, Kain KC. Disruption of CD36 impairs cytokine response to Plasmodium falciparum glycosylphosphatidylinositol and confers susceptibility to severe and fatal malaria in vivo. J Immunol. 2007 Mar 15;178(6):3954-61. | FULL TEXT PMID: 17339496 | ||
| 16 | Lu Z, Serghides L, Patel SN, Degousee N, Rubin BB, Krishnegowda G, Gowda DC, Karin M, Kain KC. Disruption of JNK2 decreases the cytokine response to Plasmodium falciparum glycosylphosphatidylinositol in vitro and confers protection in a cerebral malaria model. J Immunol. 2006 Nov 1;177(9):6344-52. | FULL TEXT PMID: 17056565 | ||
| 15 | Serghides L, Vidric M, Watts TH. Approaches to studying costimulation of human antiviral T cell responses: prospects for immunotherapeutic vaccines. Immunol Res. 2006;35(1-2):137-50. | PMID: 17003516 | ||
| 14 | Serghides L, Patel SN, Ayi K, Kain KC. Placental chondroitin sulfate A-binding malarial isolates evade innate phagocytic clearance. J Infect Dis. 2006 Jul 1;194(1):133-9. | FULL TEXT PMID: 16741892 | ||
| 13 | Serghides L, Bukczynski J, Wen T, Wang C, Routy JP, Boulassel MR, Sekaly RP, Ostrowski M, Bernard NF, Watts TH. Evaluation of OX40 ligand as a costimulator of human antiviral memory CD8 T cell responses: comparison with B7.1 and 4-1BBL. J Immunol. 2005 Nov 15;175(10):6368-77. | FULL TEXT PMID: 16272289 | ||
| 12 | Ayi K, Patel SN, Serghides L, Smith TG, Kain KC. Nonopsonic phagocytosis of erythrocytes infected with ring-stage Plasmodium falciparum. Infect Immun. 2005 Apr;73(4):2559-63. | FULL TEXT PMID: 15784606 | ||
| 11 | Serghides L, Kain KC. Peroxisome proliferator-activated receptor gamma and retinoid X receptor agonists have minimal effects on the interaction of endothelial cells with Plasmodium falciparum-infected erythrocytes. Infect Immun. 2005 Feb;73(2):1209-13. | FULL TEXT PMID: 15664966 | ||
| 10 | Patel SN, Serghides L, Smith TG, Febbraio M, Silverstein RL, Kurtz TW, Pravenec M, Kain KC. CD36 mediates the phagocytosis of Plasmodium falciparum-infected erythrocytes by rodent macrophages. J Infect Dis. 2004 Jan 15;189(2):204-13. | FULL TEXT PMID: 14722884 | ||
| 9 | Nathoo S, Serghides L, Kain KC. Effect of HIV-1 antiretroviral drugs on cytoadherence and phagocytic clearance of Plasmodium falciparum-parasitised erythrocytes. Lancet. 2003 Sep 27;362(9389):1039-41. | PMID: 14522535 | ||
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| 5 | Serghides L, Kain KC. Mechanism of protection induced by vitamin A in falciparum malaria. Lancet. 2002 Apr 20;359(9315):1404-6. | PMID: 11978340 | ||
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| 3 | Serghides L, Kain KC. Peroxisome proliferator-activated receptor gamma-retinoid X receptor agonists increase CD36-dependent phagocytosis of Plasmodium falciparum-parasitized erythrocytes and decrease malaria-induced TNF-alpha secretion by monocytes/macrophages. J Immunol. 2001 Jun 1;166(11):6742-8. | FULL TEXT PMID: 11359831 | ||
| 2 | McGilvray ID, Serghides L, Kapus A, Rotstein OD, Kain KC. Nonopsonic monocyte/macrophage phagocytosis of Plasmodium falciparum-parasitized erythrocytes: a role for CD36 in malarial clearance. Blood. 2000 Nov 1;96(9):3231-40. | FULL TEXT PMID: 11050008 | ||
| 1 | Serghides L, Crandall I, Hull E, Kain KC. The Plasmodium falciparum-CD36 interaction is modified by a single amino acid substitution in CD36. Blood. 1998 Sep 1;92(5):1814-9. | FULL TEXT PMID: 9716613 |